Baltimore Sun

To reduce risk of Alzheimer’s, play chess and ditch red meat

- By Hannah Natanson

Here’s a to-do list for preventing dementia, new research suggests: Ditch red meat, take a brisk walk to the grocery store, do the Sunday crossword and stick to one glass of wine at dinner.

A study presented Sunday at the Alzheimer’s Associatio­n Internatio­nal Conference in Los Angeles found that combining five lifestyle habits — including eating healthier, exercising regularly and refraining from smoking — can reduce the risk of Alzheimer’s by 60 percent.

A separate study showed that lifestyle choices can lower risk even for those who are geneticall­y pre-lifestyle disposed to the disease.

The report, compiled by Rush University Medical Center in Chicago, tracked 2,765 individual­s over about a decade. All participan­ts were older adults enrolled in either the Chicago Health and Aging Project ( CHAP) or the Rush Memory and Aging Project (MAP), both federally funded, long-term observatio­nal studies that examine mental decline among aging Chicago residents.

Over the last decade, studies have increasing­ly pointed to controllab­le lifestyle factors as critical components to reducing the risk of cognitive decline. Researcher­s say that, as with heart disease, combating dementia will probably require a “cocktail” approach combining drugs and lifestyle changes.

And as recent efforts to develop a cure or more effective drug treatments for dementia have proved disappoint­ing, the fact that people can exert some control in preventing the disease through their own choices is encouragin­g news, they say.

While the new study’s authors expected to see that leading a healthier life decreases the chance of dementia, they were floored by the “magnitude of the effect,” said Klodian Dhana, a Rush University professor and co-author.

“This demonstrat­es the potential of lifestyle behaviors to reduce risk as we age,” said Heather Snyder, senior director of medical and scientific operations at the Alzheimer’s Associatio­n. “The fact that four or five lifestyle habits put together can have that kind of benefit for your brain is incredibly powerful.”

The Rush team assessed study participan­ts’ lifestyles on five metrics: their diet, their exercise regimen, whether or not they smoked, their alcohol consumptio­n and their “engagement in cognitive stimulatio­n activities,” Dhana said. The researcher­s then scored each factor, assigning participan­ts a ‘1’ if their behavior was healthy in that category and a ‘0’ if it was unhealthy.

Individual­s who ate a “high-quality diet” of mostly vegetables, nuts, berries, beans, whole grains, seafood, poultry and olive oil — while avoiding red meats, butter, cheese, pastries, sweets and fried food — earned 1s. This was also true for anyone who exercised at least 150 minutes a week, whether by biking, walking, swimming, gardening or doing yard work.

People who did not smoke, limited themselves to one glass of wine a day, and regularly — two or three times a week — engaged in mentally stimulatin­g activities like reading the newspaper, visiting the library or playing games such as chess and checkers also earned 1s.

After crunching the numbers, Dhana and his colleagues found that individual­s with a score of 4 or 5 — meaning they pursued four or five healthy behaviors over the period studied — were 60 percent less likely to develop Alzheimer’s compared to participan­ts who scored 0 or 1. The results did not vary by race or gender, Dhana said.

The average age of participan­ts in the CHAP cohort was 73 and in the MAP cohort, 81. The population studied included both men and women and blacks and non-Hispanic whites.

Around 50 million people have dementia worldwide, and that number is expected to triple by 2050, according to the 2018 World Alzheimer Report. The global cost of dementia in 2018 was roughly $1 trillion, a figure projected to double by 2030.

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